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Nature MedicineArticle

From algorithms to patient outcomes — lessons from one of the first randomized trials of AI in medicine

Nature Medicine · 09/07/2026

PubMed abstract / permitted excerpt

Nature Medicine, Published online: 07 September 2026; doi:10.1038/s41591-026-04633-x The first generation of medical artificial intelligence (AI) was judged on whether algorithms could match clinicians. The next generation should be judged on whether carefully designed human–AI systems can improve patient outcomes.

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