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Comment on Pop-Busui et al. Screening Natriuretic Peptide Levels Predicts Heart Failure and Death in Individuals With Type 1 and Type 2 Diabetes Without Known Heart Failure.

Diabetes care · ADA · 08/20/2026

Authors: Fujisawa, Koshiro; Fujikawa, Tatsuya

Publication types: Letter

PubMed abstract / permitted excerpt

We read with great interest about the study by Pop-Busui et al. ( 1 ), which demonstrated the prognostic value of natriuretic peptide (NP) levels in a large, real-world cohort of 116,466 individuals with diabetes. While the association between NP levels and future risk is compelling, the definition used for incident heart failure (HF) raises important questions regarding potential bias.

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