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Nature MedicineArticle

Gene alteration in human brain suggests genetic and epigenetic roots of major depression.

Nature medicine · 09/03/2026

Publication types: Journal Article

PubMed abstract / permitted excerpt

Nature Medicine, Published online: 03 September 2026; doi:10.1038/s41591-026-04682-2 A large, multimodal molecular characterization of the adult human hippocampus provides evidence for sustained neurogenesis and identifies a stalled neurogenic process in major depressive disorder (MDD). Cell- and circuit-specific genetic, epigenetic, stress, immune, metabolic and synaptic mechanisms are identified

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